Adverse Effects of Lomotil

Lomotil in diarrhoeal illnesses.

Sir, The article by Curtis and Goel (Archives, 1979, 54, 222) prompts me to place the usage of Lomotil in young children in the tropics in its right perspective. The problems of diarrhoea in the tropics are quite different when compared with temperate climates, and management of this condition is therefore also different. In situations where children have little or no access to optimal therapeu...

Lomotil in diarrhoeal illnesses.

Lomotil poisoning in children.

45 children were admitted to hospital after ingesting varying quantities of diphenoxylate (Lomotil). One died and 44 recovered without any sequelae. Four patients were comatose, 32 were drowsy, and 9 suffered respiratory depression. No correlation was found between ingested dose and the severity of symptoms. Because of its action in rendering the gut atonic, removal of diphenoxylate by gastric ...

Sperm abnormalities: Adverse effects of thyroid dysfunction

Introduction: Despite the importance of thyroid hormones in reproduction, there are only a few studies that focus on male infertility. The objective of this study was to evaluate semen parameters in patients with hypothyroidism or hyperthyroidism. Materials and methods: Totally, 28 patients with thyroid disorders were evaluated for the semen parameters. Serum TSH and T4 concentrations were mea...

Adverse Effects of Synovectomy on Juvenile Rheumatoid Arthritis

One hundred fifty two patients with Juve­ nile rheumatoid arthritis were retrospectively studied in an effort to determine the efficacy of synovectomy in thi's disease.  Twenty-five of 117 closely observed patients underwent synovectomy following failure to be controlled by more conservative measures. Analysis of the end-results on the basis of age, sex, stage of disease, and individual joints...